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Modeling / Numerical Simulation of Protein Adsorption and Magnetic Separation

Modeling / Numerical Simulation of Protein Adsorption and Magnetic Separation
chair:Theoretisch
type:Master- or Diploma Thesis
time:As of now
tutor:

Marie-Luise Maier

In process engineering, microscopic and macroscopic scaled modeling is often of interest. For example, microscopic processes have to be taken into account to examine the adsorption of protein to surfaces of magnetic particles in a suspension (see picture). Subsequently, the particles can be separated of the fluid via magnetic forces that is to be described on macroscopic scale. Usually, for each scale an appropriate software has to be used.

 

Lindner, J.: On Continuous Magnetically Enhanced Centrifugation in Large Scale Downstream Processing of Bioproducts. München: Verlag Dr. Hut 2014.

The modeling of microscopic effects (e.g. dipole or boundary effects) can be done by particle distribution instead of average speed values that contain less information. Intermolecular forces are responsible for phase separation, thus it is not required to manipulate boundaries to depict boundary effects. To handle the rotating geometry of a magnetic separator, instead of the geometry, which is described as a static one, the fluid flowing through it is considered to be rotating by appropriate boundaries and parameters.

We use a lattice Boltzmann method to combine the different scales and to simulate the magnetic separation process. For that purpose we develop and work with the open source software OpenLB (www.openlb.net).

 

To find a topic for a master or diploma thesis, we offer theses in the files of:

  • Modelling and Simulation of Particle Flows (Magnetic Particles)
  • Fluid Structure Interaction
  • Adsorption Processes
  • Particle Deposition
  • etc.

 

For more details, please contact me.

 

Marie-Luise Maier
Geb.30.70 R 207
Tel.:0721 – 42429
E-Mail: marie-luise.maier@kit.edu